@article { author = {Salaria, Sajedeh and Beitollahi, Hadi}, title = {Sensitive Simultaneous Detection of Methyldopa and Hydrochlorothiazide on Ce3+-NiO Hexagonal Nanoparticles-Modified Electrode}, journal = {Chemical Methodologies}, volume = {5}, number = {5}, pages = {407-415}, year = {2021}, publisher = {Sami Publishing Company}, issn = {2645-7776}, eissn = {2588-4344}, doi = {10.22034/chemm.2021.134965}, abstract = {We applied GCE modified with Ce3+-NiO hexagonal nanoparticles (Ce3+-NiO HNPs) for preparing methyldopa electrochemical sensor. Electrochemical study of the modified electrode showed that within the optimal conditions of phosphate buffer solution (PBS) at a pH of 7.0 in CV, oxidation potency of methyldopa decline to ~100 mV at the modified electrode in comparison with an unmodified GCE. The sensor exhibits a sensitive response to methyldopa in range between 0.1 and 80.0 μM with a limit of detection (LOD) equal to 0.03 μM. In addition, as sensing materials for simultaneously determine hydro-chlorothiazide and methyldopa, Ce3+-NiO HNPs/GCE, exhibited high sensitivity. The defined and separated oxidation peaks of a mixture of methyldopa and hydrochlorothiazide were obtained with significant peak potential differences of 390 V. The proposed electrochemical sensor was employed in analysis of both drugs in the real specimens. }, keywords = {glassy carbon electrode,Ce3+-NiO hexagonal nanoparticles,Methyldopa,Hydrochlorothiazide,Electrochemical sensor}, url = {https://www.chemmethod.com/article_134965.html}, eprint = {https://www.chemmethod.com/article_134965_bc483e4c0e0c56342adedd1591859603.pdf} }