@article { author = {Muhiebes, Raed M. and O.Al-Tamimi, Entesar}, title = {Modification of Creatinine to Form New Oxazepane Ring and Study Their Antioxidant Activity}, journal = {Chemical Methodologies}, volume = {5}, number = {5}, pages = {416-421}, year = {2021}, publisher = {Sami Publishing Company}, issn = {2645-7776}, eissn = {2588-4344}, doi = {10.22034/chemm.2021.135020}, abstract = {In this research new creatinine Schiff bases (1a, 1b, and 1c) were synthesized from the reaction of aromatic aldehydes (4-nitrobenzaldehyde,4-amino benzaldehyde, and cinnamaldehyde) with creatinine, in few drops of glacial CH3COOH as a catalyst in C2H5OH. Then, seven-member rings were prepared (oxazepine) (2a-4c) on creatinine form treatment of imines with (phthalic, maleic, and succinic anhydrides. Synthesized compounds were identified by IR, melting point, and 1H-NMR of some of them. Some of the prepared compounds were studded with antioxidant activity.}, keywords = {Schiff base,oxazapane derivatives,Antioxidant activity}, url = {https://www.chemmethod.com/article_135020.html}, eprint = {https://www.chemmethod.com/article_135020_215ed3a827b59c4c2c1f3093f8e34b3c.pdf} }