@article { author = {Venkateswarlu, Marri and Kumar, Mukka Satish and Kamatala, Chinna Rajanna and Venkanna, Purugula and Saiprakash, Pondichery Kuppuswamy}, title = {Ultrasonic and Microwave Effects on the Benzamide/Sulfuryl Chloride Mediated Benzoylation of Benzene Derivatives under Vilsmeier-Haack Conditions}, journal = {Chemical Methodologies}, volume = {7}, number = {9}, pages = {650-658}, year = {2023}, publisher = {Sami Publishing Company}, issn = {2645-7776}, eissn = {2588-4344}, doi = {10.48309/chemm.2023.50558}, abstract = {Benzamide/ Sulfuryl Chloride (SO2Cl2) reagent has been developed as a Vilsmeier- Haack(VH) reagent for benzoylation of aromatic compounds by using the conventional and ultrasonic sonication (US), and microwave (MW) conditions. Benzoylation is much more competent and faster than the analogous VH ((Benzamide/ POCl3) or (Benzamide/ SOCl2)) reagents and afforded benzoyl derivatives in good yields.  Reaction times are moderately less than those observed with [Benzamide/ POCl3] and (Benzamide/ SOCl2) reagents. Reaction times are far less in microwave assisted (MWAR) reactions than ultrasonically assisted (USAS) reactions , which in turn are less than the conventional method with a decreasing  trend: MWAR (seconds) << Sonication (minutes) << conventional (hrs). The highly remarkable rate accelerations in MW assisted reactions are attributed to the bulk activation of the molecules; while US assisted reactions could be accounted for cavitation effects. }, keywords = {Ultrasonic and microwave irradiation,Benzamide/ SO2Cl2,Rate accelerations}, url = {https://www.chemmethod.com/article_50558.html}, eprint = {https://www.chemmethod.com/article_50558_63fe1022f839e2c28cbf3fe8541f3dbc.pdf} }