eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2020-09-01
4
5
543
553
10.22034/chemm.2020.106433
106433
مقاله پژوهشی
Fe3O4 Bonded Pyridinium-3-carboxylic acid-N-sulfonic Acid Chloride as an Efficient Catalyst for the Synthesis of 3,4-dihydropyrimidin-2(1H)-ones
Ardeshir Khazaei
khazaei_1326@yahoo.com
1
Fatemeh Gohari-Ghalil
fatmhgwhry759@gmail.com
2
Mahsa Tavasoli
mahsatavasoli@gmail.com
3
Mohammad Rezaei-Gohar
mohamadrezaei1028@gmail.com
4
Ahmad Reza Moosavi-Zare
moosavizare@yahoo.com
5
Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838683, I. R. Iran
Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838683, I. R. Iran
Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838683, I. R. Iran
Department of Chemistry, Sayyed Jamaleddin Asadabadi University, Asadabad, 6541861841, I. R. Iran
Department of Chemistry, Sayyed Jamaleddin Asadabadi University, Asadabad, 6541861841, I. R. Iran
Fe3O4bonded pyridinium-3-carboxylic acid-N-sulfonic acid chloride, as a magnetic and reusable catalyst, was reported for the one-pot multi-component synthesis of some 3,4-dihydropyrimidin-2(1H)-ones by the reaction of urea, ethyl acetoacetateand various aldehyde under solvent-free conditions. The products were identified by FT-IR, 1H NMR and 13C NMR spectra and the catalyst was reused successfully for three times.
https://www.chemmethod.com/article_106433_f84234bfff2f68c294193bb0cf54a217.pdf
3
4-Dihydropyrimidin-2(1H)-one
Fe3O4 bonded pyridinium-3-carboxylic acid-N-sulfonic acid chloride
Magnetic reusable catalyst
Solvent-free
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2020-09-01
4
5
554
564
10.22034/chemm.2020.107024
107024
مقاله پژوهشی
Cyclodehydration and Baker-Venkataraman Rearrangement Methodologies for the Preparation of Fluorinated 4H-Chromones
Chloe Fernandes
cfernandes@ggc.edu
1
Sang H. Park
spark1@ggc.edu
2
Joseph Sloop
jsloop@ggc.edu
3
Karla Wilmott
kwilmott@ggc.edu
4
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, G.A. 30043, USA
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, G.A. 30043, USA
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, G.A. 30043, USA
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, G.A. 30043, USA
Trifluoromethylated and ring-fluorinated 4H-chromones have been prepared via cyclodehydration and via the baker-venkataraman rearrangement. The cyclodehydration of 4,4,4-trifluoro-1-(1-naphthol-2-yl)-1,3-butanedione was performed under a variety of base promoted and acid catalyzed processes enroute to 2-trifluoromethyl-β-naphthochromone. Using microwave irradiative, sonication and conventional processes, selected o-hydroxyaromatic ketones underwent single-pot, based promoted baker-venkataraman rearrangements with trifluoroacetic anhydride to give trifluoromethylated 4H-chromones in yields ranging from 50-82%. Microwave irradiation conditions allowed for yields ranging from 50-80%, which compare favorably to yields achieved via conventional methods (60-82%) as well as reducing reaction times by 55% compared to conventional refluxing conditions.
https://www.chemmethod.com/article_107024_861a1f334c60ed0d246fa2bd8e116c75.pdf
1,3-Diketone
trifluoroacetic anhydride
fluorinated chromone
Solvent-free reaction
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2020-09-01
4
5
565
571
10.22034/chemm.2020.107071
107071
مقاله پژوهشی
Alumina-Supported Cobalt Nanoparticles Efficiently Catalyzed the Synthesis of Chromene Derivatives under Solvent-Free Condition
Jalal Albadi
chemalbadi@gmail.com
1
Heshmat allah Samimi
samimi-h@sci.sku.ac.ir
2
Ahmad reza Momeni
ahmadrmomeni@yahoo.com
3
Department of Chemistry, Faculty of Sciences, Shahrekord University, Shahrekord, Iran
Department of chemistry, Faculty of sciences, Shahrekord University, Shahrekord, Iran
Department of Chemistry, Faculty of Sciences, Shahrekord University, Shahrekord, Iran
In this research study, an efficient approach is reported for the solvent-free synthesis of various chromene derivatives catalyzed by alumina-supported cobalt nanoparticles in high yields. Alumina-supported cobalt nanoparticles (Co/Al2O3 nanocatalyst), efficiently catalyzed the reaction between the resorcinol or 2-hydroxy naphthalene with benzaldehyde and malononitrile into chromene derivatives in high efficiency. This procedure allowed us to obtain corresponding products in short reaction times, simple work-up, and high yields. Experimental procedure with Co/Al2O3 nanocatalyst is very simple and the catalyst is easily removed by filtration. The catalyst was also found to be recyclable and can catalyze synthesis of the chromenes up to 5 times well.
https://www.chemmethod.com/article_107071_f9ff3a8a066620f13957b8b75993170b.pdf
Co/Al2O3 nanocatalyst
nanocatalyst
Resorcinol
2-hydroxy naphthalene
Chromenes
Solvent-free condition
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2020-09-01
4
5
572
583
10.22034/chemm.2020.107198
107198
مقاله پژوهشی
Comparison of Different Extracts of Nettle in Quercetin and Evaluation of its Antimicrobial Activity
Mahsa Taghvaei
mahsataghvaei2018@gmail.com
1
MohamMad Fazilati
dr.moh.faz@gmail.com
2
Habibollah Nazem
hnazem@pnu.ac.ir
3
Saeed Habibollahi
s.habibollahi@pnu.ac.ir
4
Faegh Bastani
faeghbastani@yahoo.com
5
Department of Biochemistry, Payame Noor University, 81581-84431, Isfahan, Iran
Department of Biochemistry, Payame Noor University, 81581-84431, Isfahan, Iran
Department of Biochemistry, Payame Noor University, 81581-84431, Isfahan, Iran
Department of Biochemistry, Payame Noor University, 81581-84431, Isfahan, Iran
Department of Biochemistry, Payame Noor University, 81581-84431, Isfahan, Iran
Nettle (Urtica dioica L.) is one of the most well-known medicinal plants. It has been mostly used for medical purposes. This study summarizes extensive results on the antimicrobial effect of Urtica dioica L. The aim of this study was to investigate several extraction methods of nettle extract for more access to flavonoid materials especially quercetin. For this purpose, three methods (soaking, sonication, soxhlet) and three solvents (chloroform, methanol, deionized water) were used for extraction. Finally, the highest amount of quercetin determined by HPLC was sonication for 90 min with methanol solvent. The effect of this extract was investigated on several pathogenic microbes including Escherichia coli, Entrecoccus faecalis, Klebsiella pneumoniae, Acinetobacter calcoaceticus, Candida albicans. Antibiogram testing revealed that Escherichia coli and Candida albicans were resistant to nettle extract, Acinetobacter calcoaceticus and Klebsiella pneumonia, were sensitive and Enterococcus faecalis was semi-susceptible.
https://www.chemmethod.com/article_107198_d50c71817a3e4c6afb22a21b7a4f5373.pdf
Nettle
Quercetin
HPLC
Antibiogram
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2020-09-01
4
5
584
594
10.22034/chemm.2020.107202
107202
مقاله پژوهشی
DFT-PCM Study on Structures of Phthalazinone Tautomers
Mohammad Ali Bodaghifard
mbodaghi2007@yahoo.com
1
Sajad Asadbegi
sajad.asadbegi@gmail.com
2
Mahdia Hamidinasab
mahdiahamidinasab@yahoo.com
3
Department of Chemistry, Faculty of science, Arak University, Arak 38156-8-8349, Iran
Department of Chemistry, Faculty of science, Arak University, Arak 38156-8-8349, Iran
Department of Chemistry, Faculty of science, Arak University, Arak 38156-8-8349, Iran.
In this research study, relative stability of all the tautomers of phthalazinone ring in the gas phase and the solvent effect on the tautomeric equilibrium were evaluated using the density functional theory-polarizable continuum model at the B3LYP/6-311++G(d,p) basis set. In addition, variation of the dipole moments in the gas phase and solution, the specific solvent effect on the transition state of proton transfer assisted by a water molecule and the NBO calculated charges on the atoms were investigated. The water-assisted tautomerization with one molecule revealed that, the free energy activation barrier was reduced compared to those for the uncatalyzed systems. In the all the tautomers of phthalazinone rings, when going from gas phase to more polar solvents, the net charges on the O atoms slightly increased.
https://www.chemmethod.com/article_107202_c1b0ca3e7407921e61db728f1ef61d3d.pdf
DFT
Tautomerization
Solvent effect
Transition State
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2020-09-01
4
5
595
604
10.22034/chemm.2020.107203
107203
مقاله پژوهشی
Effect of External Electric Field and Temperature on Entropy, Heat of Capacity, and Chemical Reactivity with QSAR Study of Morphonium Chloride and Nitrous Ionic Liquids Crystal Using DFT
Ajoy Kumer
kumarajoy.cu@gmail.com
1
Mohammad Jahidul Islam
jahidulkhan106490@gmail.com
2
Sunanda Paul
paulsunanda.bmb@gmail.com
3
Department of Chemistry, European University of Bangladesh, Dhaka-1216, Bangladesh
Department of Physics, European University of Bangladesh, Dhaka-1216, Bangladesh
Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong,Hathazari-4334, Bangladesh
Due to the great number of medicinal application of morphine in drugs, the morphonium chloride (IL01) and morphonium nitrous (IL02) were investigated using the computational method to assess their biological activity. The quantitative structure activity relationship (QSAR) parameters for instance, charge density, surface area grid, volume, LogP, polarizability, refractivity, and molecular mass were demonstrated through the density functional theory (DFT) for simulation as well as the chemical reactivity like HOMO, LUMO, and HOMO, LUMO gap were also calculated. In addition, the most important thermodynamic properties such as entropy and heat of capacity were calculated using DFT method. The values of the initial entropy and heat of capacity were zero without applying temperature. At 273 K, the entropy and heat of the capacity are 0.117, 0.113, and 0.062, 0.055 kcal/mol-deg for IL01 and IL02, respectively, which finally increased by 0.177, 0.162 and 0.120, 0.099 kcal/mol-deg at 523 K. When electric field was applied on IL01, and IL02, the entropy was decreased by 32.47% and 2.65% whereas the heat of capacity was decreased by 79.03% and 1.81%, respectively. Finally, in same electric field with increasing temperature, the entropy was enhanced by 16.45% and 45.45% besides the heat of capacity was increased about 100% at 523 K and IL02 was found to be less response compared with that of the IL01 at low temperature for electric filed but almost similar response at high temperature.
https://www.chemmethod.com/article_107203_5fa3ddcece00d021a30dbd4a5c4d4d42.pdf
Morphine
DFT
electric field
QSAR
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2020-09-01
4
5
605
613
10.22034/chemm.2020.107736
107736
مقاله پژوهشی
First Order Derivative Spectrophotometric Estimation of Ranolazine and Metformin Hydrochloride in Synthetic Mixture
Amitkumar J. Vyas
1
Disha H. Raval
disharaval56@gmail.com
2
Ajay I. Patel
3
Ashok B. Patel
4
Nilesh K. Patel
5
Alpesh chudasama
6
B.K. Mody Government Pharmacy College, New England Avenue, Piscataway, NJ, Near Aji Dam, Rajkot, Gujarat, India, Postal code: 360003
B.K. Mody Government Pharmacy College, New England Avenue, Piscataway, NJ, Near Aji Dam, Rajkot, Gujarat, India, Postal code: 360003
B.K. Mody Government Pharmacy College, New England Avenue, Piscataway, NJ, Near Aji Dam, Rajkot, Gujarat, India, Postal code: 360003
B.K. Mody Government Pharmacy College, New England Avenue, Piscataway, NJ, Near Aji Dam, Rajkot, Gujarat, India, Postal code: 360003
B.K. Mody Government Pharmacy College, New England Avenue, Piscataway, NJ, Near Aji Dam, Rajkot, Gujarat, India, Postal code: 360003
Amneal pharmaceutical LLC, Murray Road, Hanover, NJ 07936, USA
This research study aimed at developing and validating a simple, precise, accurate, specific and economical spectrophotometric method for simultaneous estimation of Ranolazine (RANO) and Metformin hydrochloride (MET) in synthetic mixture. This method is based on first order derivative spectroscopy.Ranolazine and Metformin hydrochloride exhibited absorbance at working wavelength 232.86 nm (Zero crossing point of Metformin hydrochloride) and 249.29 nm (zero crossing point of Ranolazine) respectively using water as a diluent. This method was validated as per ICH guideline. Linearity was established over the concentration range of 2-35 μg/mL both of Ranolazine and Metformin hydrochloride with correlation coefficients 0.999 and 0.998, respectively. Accuracy was obtained between 98.48-101.85% and 98.25-100.88% for Ranolazine and Metformin hydrochloride respectively. LOD and LOQ were found to be 0.08 μg/mL and 0.25 μg/mL for Ranolazine and 0.25 μg/mL and 0.77 μg/mL for Metformin hydrochloride, respectively.The results revealed that, the developed method was suitable for the routine analysis of determination of Ranolazine and Metformin hydrochloride in combine dosage form. Keywords: Ranolazine; Metformin hydrochloride; First order derivative; UV spectrophotometry; ICH guideline
https://www.chemmethod.com/article_107736_64a7dc1a44584d4af9cfdcf6838e7792.pdf
ranolazine
Metformin hydrochloride
First order derivative
UV spectrophotometry
ICH guideline
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2020-09-01
4
5
614
622
10.22034/chemm.2020.108145
108145
The Synthesis of α,αʹ-bis(arylidene)Cycloalkanones using Sulfonic Acid Functionalized Pyridinium Chloride
Ahmad Reza Moosavi-Zare
moosavizare@yahoo.com
1
Mohammad Ali Zolfigol
mzolfigol@yahoo.com
2
Zahir Rezanejad
zahirrezanejad@yahoo.com
3
Sayyed Jamaleddin Asadabadi University, Asadabad, 6541861841, I. R. Iran
Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838683, Iran
Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838683, Iran
In this study, condensation reaction of the aldehydes with various ketones in the presence of sulfonic acid functionalized pyridinium chloride [pyridine–SO3H]Cl as an ionic liquid and catalyst were carried out to prepare the α,αʹ- bis(arylidene)cycloalkanone under the solvent free conditions. The purity and yield of the products were high and their identification was performed by the spectroscopic analysis and comparison of the physical information with known compounds in the previous literature.
https://www.chemmethod.com/article_108145_e8198e2b28027cf6836dc2994cde90f6.pdf
Sulfonic acid functionalized pyridinium chloride
cross-aldol condensation
α
αʹ- bis(arylidene)cycloalkanone
Solvent-free
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2020-09-01
4
5
623
634
10.22034/chemm.2020.108149
108149
مقاله پژوهشی
Acidic Ionic Liquid Based Silica-Coated Fe3O4 Nanoparticles as a New Nanomagnetic Catalyst for Preparation of Aryl and Heteroaryl Thiocyanates
Sami Sajjadifar
ss.sajjadifar@gmail.com
1
Issa Amini
issaamini5548@gmail.com
2
Sepideh Habibzadeh
spdh.hab@gmail.com
3
Ghobad Mansouri
mansouri.gh@gmail.com
4
Esfandeyar Ebadi
esfand1370@gmail.com
5
Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran
Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran
Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran
Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran
Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran
In this research study, acidic ionic liquid based silica-coated Fe3O4 nanoparticles [Fe3O4@SiO2@(CH2)3-Py]HSO4as an efficient and reusable magnetic nanocatalyst was synthesized and characterized using the FT-IR, TEM, VSM, XRD, and TGA analysis. The catalytic performance of the [Fe3O4@SiO2@(CH2)3-Py]HSO4was evaluated towards the regioselective thiocyanation of aromatic and heteroaromatic compounds with KSCN as a thiocyanate source afforded the corresponding aryl and heteroaryl thiocyanates derivatives 2a-n at room temperature in H2O2 as a clean oxidant and ethanol as a green solvent. A broad range of products 2a-n was synthesized high yields (up to yield 97%) under the mild reaction conditions.
https://www.chemmethod.com/article_108149_e3eb2f7e073bef8a0c57739aa77a3a18.pdf
Thiocyanation
Nanomagnetic catalyst
Mild oxidant
Aromatic and heteroaromatic compounds
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2020-09-01
4
5
635
646
10.22034/chemm.2020.109508
109508
مقاله پژوهشی
Aluminum in Reaction with Sodium Hydroxide: Summary Action of a Depolarizer and an Inhibitor
Sikachina Andrey Anatolevicha
sikachina@list.ru
1
Beloglazov Sergey Michailovich
smbeloglazov@mail.ru
2
Beloglazov Georgy Sergeevich
drgeorge59@mail.ru
3
School of Life Science, Immanuel Kant Baltic Federal University, Kaliningrad-City, Russian Federation
School of Life Science, Immanuel Kant Baltic Federal University, Kaliningrad-City, Russian Federation
Associate Professor, Perm Pharmaceutical Academy, Professor, Dodoma University, Department of Physics, United Republic of Tanzania
An unusual work is that the galvanic cell described is non-standard and has irreversible electrodes. Non-standard are comparative electrodes too. Only 1 electrochemical cell Al | NaOH (it is polarizer, amperage-forming or polarizing agent). By measuring the amperage generated by this electrochemical cell, the dissolution rate of aluminum was investigated. Inhibition of aluminum dissolution was supposed to be achieved for the first time using the “Dorogov antiseptic stimulator of fraction No. 2” or ASD-2F, acceleration by the introduction of a depolarizer (it is depolarizing or amperage-absorbing agent) consisting of steel and copper cores protected from vortex flows caused by anything. The amperage and voltage characteristics “amperage on polarizer + depolarizer-\-voltage on depolarizer” were built. The fastest dissolution occurs when a larger voltage accounts for a larger voltage. A correlation was revealed "the ionic strength of the inhibitor at the N and O atoms of 2nd...5th groups of "organic-part" of ASD-2F IΣ2 ....5 \ amperage of a galvanic cell for 600 mV", and a correlation was revealed "donor and acceptor strength of molecules of 2nd - 5th groups of "organic-part" of ASD-2F HΣ2...5 \ amperage of a galvanic cell for 600 mV». It is very important that each line of each diagram is analyzed individually.
https://www.chemmethod.com/article_109508_bf683f67d3930e9d4cbc30d0dcb6bb64.pdf
Galvanic cell
voltage and amperage characteristic
depolarization
hydrogen
Pearson's correlation coefficients
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2020-09-01
4
5
647
659
10.22034/chemm.2020.109841
109841
مقاله پژوهشی
Salicylic Acid as a Bio-based and Natural Brønsted Acid Catalyst Promoted Green and Solvent-free Synthesis of Various Xanthene Derivatives
Farzaneh Mohamadpour
mohamadpour.f.7@gmail.com
1
Mansoor Feilizadeh
ehsan.feilizadeh@gmail.com
2
School of Engineering, Apadana Institute of Higher Education, Shiraz, Iran
Department of Chemical Engineering, Engineering Faculty, Ferdowsi University of Mashhad, Mashhad, Iran
In this research study, a green protocol for facile and eco-safe synthesis of 12-aryl-tetrahydrobenzo[α]xanthene-11-ones, 1,8-dioxo-octahydroxanthenes and 14-aryl-14H-dibenzo[α,j]xanthenes using salicylic acid as a bio-based and natural Brønsted acid catalyst in a one-pot, multi-component synthesis under solvent-free conditions is reported. The present methodology is an environmentally friendly approach for the synthesis of various xanthene derivatives. It also offers several merits including, good yields, short reaction times, efficient, eco-friendly, solvent-free conditions, and materials available
https://www.chemmethod.com/article_109841_feebeced060ca107a6816fbac0429832.pdf
Salicylic Acid
Bio-based and natural conditions
12-Aryl-tetrahydrobenzo[α]xanthene-11-ones
1,8-dioxo-octahydroxanthenes
14-Aryl-14H-dibenzo[α,j]xanthenes
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2020-09-01
4
5
660
670
10.22034/chemm.2020.109975
109975
مقاله پژوهشی
Potentiometric Determination of La(III) Using Chitosan Modified Carbon Paste Electrode with An experimental Design
Negar Rajabi
negarrajabi87@gmail.com
1
Mahboubeh Masrournia
mah.masrour@gmail.com
2
Mohamadreza Abedi
mohamadrezaabedi@yahoo.com
3
Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Department of Applied Chemistry, Quchan Branch, Islamic Azad University, Quchan, Iran
In this work, D-optimal mixture design was applied as an experimental design to screen and optimize the effect of the composition of a carbon paste on its performance. In this study, chitosan was offered as a ligand for the determination of La(III) with the carbon paste electrode. In the fabricated sensor, the greatest nernstian slope was achieved on the optimized mixture composition by experimental design: 60.00% w/w powder graphite, 1.53% w/w multi-walled carbon nanotubes (MWCNTs), 29.79% w/w paraffin oil, and 8.68% w/w chitosan. MWCNT was used for increasing the electrode response to La(III). The quadratic fitting pattern based on D-optimal model was used to find the desirability functions of the suggested design to assess the cross-interferences and the interactions between the factors. The fabricated sensor for determining the La(III) ions demonstrated a maximum nernstian slope equal to 19.70 mV.decade-1 along a linear range from 1.0×10−6 to 1.0×10−2 mol/L−1 and detection limit of 10−6 mol/L-1. The designed sensor was successfully tested in the pH range of 2-9 with suitable selectivity, fast response time (about 30 s) and long lifetime (over 2 months) was obtained without any deviation. The offered electrode was used successfully as an indicator in the potentiometric titration of La(III) with EDTA.
https://www.chemmethod.com/article_109975_036ca0a9e34db502877cf169d39adabc.pdf
Lanthanum selective electrode
Multi-walled carbon nanotubes
Modified carbon paste electrode
Chitosan