eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2019-03-01
3
2
145
165
10.22034/chemm.2018.135684.1063
74994
Development and Validation of Stability Indicating HPLC Method for the Determination of Process and Degradation Related Impurities in Telmisartan Drug Substance
Balakrishna Ganni
ganni.balakrishna@gmail.com
1
Rajesh Kumar
rajeshks54@gmail.com
2
Mohit Jain
1008mohit@gmail.com
3
Vijaya B. Kumar
vijayakumarb@microlabs.in
4
Sujeet Shrivastava
sujeetshrivastava@microlabs.in
5
Pramod Kumar
pramodkumar@microlabs.in
6
Micro Labs Ltd., API R&D centre, Bommasandra Jigani Link Road, KIADB INDL Area, Bommasandra, Bangalore-560105, Karnataka, India
Micro Labs Ltd., API R&D centre, Bommasandra Jigani Link Road, KIADB INDL Area, Bommasandra, Bangalore-560105, Karnataka, India
Micro Labs Ltd., API R&D centre, Bommasandra Jigani Link Road, KIADB INDL Area, Bommasandra, Bangalore-560105, Karnataka, India
Micro Labs Ltd., API R&D centre, Bommasandra Jigani Link Road, KIADB INDL Area, Bommasandra, Bangalore-560105, Karnataka, India
Micro Labs Ltd., API R&D centre, Bommasandra Jigani Link Road, KIADB INDL Area, Bommasandra, Bangalore-560105, Karnataka, India
Micro Labs Ltd., API R&D centre, Bommasandra Jigani Link Road, KIADB INDL Area, Bommasandra, Bangalore-560105, Karnataka, India
A new sensitive, specific, precise and accurate stability indicating reverse phase high performance liquid chromatographic (RP-HPLC) method was developed and validated for the determination of related substances of telmisartan drug substance. The method was developed to separate possible degradation and process related impurities. The method was developed on symmetry shield RP 8 (150 mm x 4.6 mm, 3.5 µm) column using 0.05% trifluoroacetic acid and acetonitrile as mobile phase in gradient elution. The eluents were monitored at 230 nm by UV-Visible detector. Telmisartan and its eleven impurities were well resolved by using these conditions. The limit of detection (LOD) for telmisartan and each of its impurities (Impurity-II, Impurity-III, Impurity-IV, Impurity-V, Impurity-VI, Impurity-VII, Impurity-IX, Impurity-X, Impurity-XI) were 0.01 (% w/w) and that of Impurity-I, Impurity-VIII were 0.02 (% w/w). The limit of quantitation (LOQ) for telmisartan and each of its impuries (Impurity-II, Impurity-III, Impurity-IV, Impurity-V, Impurity-VI, Impurity-VII, Impurity-IX, Impurity-X, Impurity-XI) were 0.03 (% w/w) and that of Impurity-I and Impurity-VIII peaks were 0.05 (% w/w). Forced degradation studies were performed and mass balance was established for acid, base, oxidative, photolytic, thermal and temperature and humidity degradation conditions. The method was validated as per international conference on harmonization of technical requirements for pharmaceuticals for human use (ICH) guidelines. The impurities (Impurity-VI to Impurity XI) were related to route of synthesis and the developed method was capable to quantify these impurities along with impurities (Impurity-I to Impurity-V) as per United States, European pharmacopeia.
https://www.chemmethod.com/article_74994_4df123a5eb200cae3556b51591d669c1.pdf
Telmisartan drug substance
Validation
ICH
Stability indicating
Forced degradation
RP-HPLC
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2019-03-01
3
2
166
182
10.22034/chemm.2018.145347.1077
74110
مقاله پژوهشی
Quantification of a Neuroprotective Agent Edaravone by Stability Indicating TLC Method and UV–Visible Spectroscopic Method in Bulk and Pharmaceutical Dosage Form
Jaineel Desai
jaineeldesai2@gmail.com
1
Usmangani Chhalotiya
usmangani84@gmail.com
2
Himani B. Dalwadi
hbdalwadi@gmail.com
3
Anjali M. Thakkar
anjalithakkar786@gmail.com
4
Dimal A. Shah
dimalgroup@gmail.com
5
Department of Pharmaceutical chemistry and Analysis, Indukaka Ipcowala College of Pharmacy, Beyond GIDC, P.B. No. 53, Vitthal Udyognagar- 388 121, Gujarat, India
Department of Pharmaceutical chemistry and Analysis, Indukaka Ipcowala College of Pharmacy, Beyond GIDC, P.B. No. 53, Vitthal Udyognagar- 388 121, Gujarat, India
Department of Pharmaceutical chemistry and Analysis, Indukaka Ipcowala College of Pharmacy, Beyond GIDC, P.B. No. 53, Vitthal Udyognagar- 388 121, Gujarat, India
Department of Pharmaceutical chemistry and Analysis, Indukaka Ipcowala College of Pharmacy, Beyond GIDC, P.B. No. 53, Vitthal Udyognagar- 388 121, Gujarat, India
Department of Pharmaceutical Chemistry and Analysis, Babaria Institute of Pharmacy, Vernama, Vadodara, Gujarat, India
An accurate, sensitive, reproducible and precise stability indicating thin layer chromatographic method and UV-Visible spectroscopic method was established for the amelioration and validation of neuroprotective agent edaravone in bulk and its pharmaceutical dosage form. Edaravone injection is used to treat amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease; a condition in which the nerves that control muscle movement slowly die, causing the muscles to shrink and weaken). Edaravone injection is in a class of medications called antioxidants. The high Performance thin layer chromatographic method was developed with proposed chromatographic condition with mobile phase containing n-Hexane: ethyl acetate (7:3, v/v). Accomplishment of UV–Visible spectroscopic determination was done at wavelength maxima of 245 nm using methanol as a solvent. The linearities were in the range of 1-9 µg/ml for UV-Visible spectroscopic method and 100-1400 ng/band for TLC method, respectively. Validation of proposed method has been accomplished with respect to linearity, accuracy, precision, specificity and robustness. For acid and alkali hydrolysis, chemical oxidation, dry heat degradation and photolytic degradation conditions were performed using stock solution of EDA, and quantification which has been achieved by proposed TLC method. Owing to sensitivity, promptness and accuracy of methods, we rely on both intended methods which will be useful for the regular quality control analysis and quantification of drug in bulk and pharmaceutical dosage form.
https://www.chemmethod.com/article_74110_b40c25f0bfb6fdb3f1b0d4fd5a0d3de4.pdf
Validation
Edaravone
Forced degradation study
TLC, UV–Visible spectroscopy
Neuroprotective
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2019-03-01
3
2
183
193
10.22034/chemm.2018.144016.1073
75190
مقاله پژوهشی
Preparation of Graphene/Graphene Oxide Microsupercapacitor by Using Laser-Scribed Method
Shahab Khameneh Asl
sshahab_kh@yahoo.com
1
Majed Namdar
shah.kh.asl@gmail.com
2
New materials Lab., University of Tabriz, Tabriz, Iran, P.O.Box: 5166614766
New materials Lab., University of Tabriz, Tabriz, Iran, P.O.Box: 5166614766
Graphene is a flat layer of carbon atom, and is a layer of graphite with a thickness of a few tenths of a nanometer that, due to its porous structure and high ionic transfer rate, has been considered in electronic applications, such as cloud storage capacitors with high energy. In this research work, laser-scribed technique has been regarded to synthesize graphene on the surface of a DVD with simples laser equipment and manufacture graphene and graphene composite supercapacitors for the first time without masking. For this purpose, first, by Hummer's method, graphite was converted to graphene oxide (GO) in an acidic environment containing sodium nitrate, potassium permanganate and sulfuric acid. Centrifuges and ultrasonic devices were utilized for the homogenization of graphene oxide solution. GO homogeneous solution was applied on the surface of specific DVDs and the set was dried at room temperature. For GO reduction and its transformation into graphene, a suitable laser, with programming of supercapacitor particular pattern was used. By applying energy with the amount of resonance frequency of graphene and oxygen bond, the laser broke the connection and the reduction in action and reaching to graphene was done. Thus, the optimal wavelength of laser was determined to reduce the GO. In this study, the process of graphene synthesis and applying the supercapacitor specific pattern were carried out in single step that is the biggest advantage of laser-scribed graphene (LSG) method. In present study, TEM was utilized to examine the mono layered structure of GO, SEM was used for microstructural studies of prepared arrays, two tests of cyclic voltammetry (CV) and galvanostatic charge/discharge (CC) were applied to study the performance and power of energy storage in supercapacitors (10 F/g) that six order higher than normal G supercapacitors with repeatability 95% in 10000 cycles, the XPS was used to investigate elements present in the layer applied on DVD, and the Raman spectroscopy was applied to investigate the quality of prepared graphene through studying G and D peaks.
https://www.chemmethod.com/article_75190_6466966084b1aea3253c1acfd72c75d0.pdf
graphene
Laser Scribed Graphene
lithography
Synthesis
Hummer's method
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2019-03-01
3
2
194
210
10.22034/chemm.2018.147492.1083
75430
مقاله پژوهشی
Design and Synthesis of a Diaza-bicyclo-naphthalen-oxiranyl-methanone Derivative. Theoretical Analysis of Their Interaction with Cytochrome P450-17A1
Lauro Figueroa-Valverde
lauro_1999@yahoo.com
1
Diaz Francisco
stybium@yahoo.com
2
Rosas-Nexticapa Marcela
romar@yahoo.com
3
Mateu-Armand Virginia
vikyoil@hotmail.com
4
Montano-Tapia Elizabeth
montanoti9@yahoo.com
5
Lopez-Ramos Maria
marylopez54@yahoo.com
6
García-Cervera Elodia
garcigarci56@yahoo.com
7
Pool Gómez Eduardo
pool87pol@yahoo.com
8
Hau-Heredia Lenin
leninhere90@yahoo.com
9
Alfonso-Jimenez Alondra
alondrajkl@yahoo.com
10
Cabrera-Tuz Jhair
jhairtyty5@yahoo.com
11
Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P.24039 Campeche Cam., México
Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, México, D.F. C.P. 11340
Facultad de Nutrición, Universidad Veracruzana. Médicos y Odontólogos s/n, 91010, Xalapa, Veracruz. México
Facultad de Nutrición, Universidad Veracruzana. Médicos y Odontólogos s/n, 91010, Xalapa, Veracruz. México
Facultad de Nutrición, Universidad Veracruzana. Médicos y Odontólogos s/n, 91010, Xalapa, Veracruz. México
Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P.24039 Campeche Cam., México
Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P.24039 Campeche Cam., México
Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P.24039 Campeche Cam., México
Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P.24039 Campeche Cam., México
Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P.24039 Campeche Cam., México
Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P.24039 Campeche Cam., México
Several agents have been used for the treatment of prostate cancer such as flutamide, galeterone, abiraterone and others; however, some of these drugs can produce some secondary effects. The aim of this study was to synthesize a diaza-bicyclo-naphthalen-oxiranyl-methanone derivative using some chemical tools. The structure of all compounds involved in this study was confirmed by spectroscopy and spectrometry data. In addition, the theoretical interaction of diaza-bicyclo-naphthalen-oxiranyl-methanone derivative with the cytochrome P450-17A1 enzyme (3RUK) was evaluated in a docking model using some drugs such as galeterone and abiraterone as controls. The results showed that diaza-bicyclo-naphthalen-oxiranyl-methanone could interact with different types of amino acid residues involving 3RUK protein surface as compared to both galeterone and abiraterone. This phenomenon may be due to the differences in the chemical structure of compounds. All these data indicate that diaza-bicyclo-naphthalen-oxiranyl-methanone derivative could change the biological activity of cytochrome P450-17A1 enzyme which may be translated as good candidates for prostate cancer.
https://www.chemmethod.com/article_75430_45f226cf55e2ab9a90979a221c99c8e1.pdf
Diaza-bicyclo-naphthalen-oxiranyl-methanone
derivative
Prostate Cancer
Cytochrome P450 17A1
Docking
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2019-03-01
3
2
211
225
10.22034/chemm.2018.147111.1084
75613
مقاله پژوهشی
Effect of Trimethoprim Inclusion Complexation with Cyclodextrins on its Antimicrobial Activity
Pranjali W. Chandurkar
pranjalichandurkar@gmail.com
1
Tushar A. Shinde
tushar.shinde176@gmail.com
2
Anup M. Akarte
anup_akarte@rediffmail.com
3
P.P. Raichurkar
pp.raichurkar@nmims.edu
4
Assistant Professor, SVKMS, NMIMS, MPTP, Centre for Textile Functions, Shirpur, 425405, India
Assistant Professor, SVKMS, NMIMS, MPTP, Centre for Textile Functions, Shirpur, 425405, India
Assistant Professor, KVPS, Institute of Pharmaceutical Education Boradi, Shirpur, 425428, India
Associate Dean, SVKMS, NMIMS, MPTP, Centre for Textile Functions, Shirpur, 425405, India
The aim of present study is to highlight the effects of β-cyclodextrin (BCD) and hydroxypropyl-β-cyclodextrin (HBCD) and also the effect of their concentrations and methods of inclusion complexation on solubility and antibacterial activity of trimethoprim [TMP] by inclusion complex formation. The inclusion complexes of TMP were prepared by solvent evaporation, spray drying, kneading and physical mixture methods in 1:1 and 1:2 ratios. The inclusion complexes were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), dissolution study and antimicrobial activity by disk diffusion method. Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) results proved formation of inclusion complex of TEM with cyclodextrins. XRD showed decrease in crystanality of TEM after complexation with CDs. The results of saturation solubility study and release study prevailed the more increase in solubility of TMP by HPCD than BCD. The antibacterial activity of TMP was found to be increased with the complexation process. An increase in concentration of CD increased the dissolution and the antibacterial activity.
https://www.chemmethod.com/article_75613_0bbbd5fa75158c6ed0a7a94a9497b9cf.pdf
Trimethoprim
Cyclodextrins
inclusion complex
Antimicrobial activity
Disk diffusion method
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2019-03-01
3
2
226
236
10.22034/chemm.2018.147943.1086
75614
مقاله پژوهشی
Characterization of Catalyst: Comparison of BrØnsted and Lewis Acidic Power in Boron Sulfonic Acid as a Heterogeneous Catalyst in Green Synthesis of Quinoxaline Derivatives
Sami Sajjadifar
ss.sajjadifar@gmail.com
1
Vahid Azizkhania
2
Kaushik Pal
kaushikphysics@gmail.com
3
Hadi Jabbari
hadijabbari@yahoo.com
4
Omidali Pouralimardan
pouralimardan@gmail.com
5
Faten Divsar
divsar@gmail.com
6
Sarvin Mohammadi-Aghdam
sarvin.s108@yahoo.com
7
Issa Amini
issa_amini@ymail.com
8
Hoda Hamidi
hamidi_hoda@yahoo.com
9
Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran
Department of Chemistry, Payame Noor University, P.O. Box 19395-4697, Tehran, Iran
Department of Nanotechnology, Bharath University, BIHER Research Park, Chennai, Tamil Nadu 600073, India
Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran
Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran
Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran
Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran
Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran
Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran
A simple, highly efficient and green procedure for the condensation of aryl and alkyl 1,2-diamines with α-diketones in the presence of catalytic amount of boron sulfonic acid (BSA) and silica trimethyl borat (STMB) and silica triisopropyl borate (STIPB), as two novel heterogeneous Lewis acid catalysts at room temperature, is described. In this method, we proved that the BrØnsted acidic power of boron sulfonic acid (BSA) is more important than its Lewis acidity. Using this method, quinoxaline derivatives as biologically interesting compounds are produced in high to excellent yields.
https://www.chemmethod.com/article_75614_6d003742182fec781afc8441f34e51b6.pdf
Quinoxaline
Boron Sulfonic Acid
Trimethyl borate
Triisopropyl borate
SBSA
STMB
STIPB
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2019-03-01
3
2
237
250
10.22034/chemm.2018.149025.1088
75637
مقاله پژوهشی
An Efficient Method for Synthesis of Some Novel Spiro[indoline-thiazolidine]dione Derivatives
Masoumeh Divar
zhaledivar@gmail.com
1
Soghra Khabnadideh
khabns@sums.ac.ir
2
Razieh Sabet
sabet_r@sums.ac.ir
3
Kamiar Zomorodian
zomorodian@sums.ac.ir
4
Neda Ershadi
neda_ershadin1370@yahoo.com
5
Forough Hassanpour
feerhpr@yahoo.com
6
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Faculty of Pharmacy, International Branch, Shiraz University of Medical Sciences, Shiraz, Iran
Center of Basic Researches in Infectious Diseases and Department of Medical Mycology and Parasitology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Faculty of Pharmacy, International Branch, Shiraz University of Medical Sciences, Shiraz, Iran
Faculty of Pharmacy, International Branch, Shiraz University of Medical Sciences, Shiraz, Iran
A facile synthesis of eighteen’s novel derivatives of spiro[indole-thiazolidine]diones (5a-5r) has been developed via hitherto unknown schiff bases. In the first step, we alkylated the isatin ring using different alkyl halides in DMF and in the presence of potassium carbonate and tert-butyl ammonium bromide to get 1a-1i. In the second step, N-substituted isatin (1a-1i) reacted with different amine compounds (2a-2f) to get schiff base intermediates (3a-3r). In the third step, cyclocondensation reaction with mercaptoacetic acid afforded a new class of spiro diones. The amine moieties which are used in the second step of this synthesis are varied from aniline derivatives (2a-2d), phenylpyrazole (2e) and oxazole (2f) analogues. Of the 18 final new compounds 9 analogues derived from aniline, 2 analogues derived from oxazole and 7 of them synthesized from phenylpyrazole analogues. Chemical structures of all new compounds were confirmed by spectroscopic methods such as IR, HNMR and CNMR.
https://www.chemmethod.com/article_75637_a99b040e950fa255bdffec38af499b67.pdf
Spiro compounds
Isatin
Cyclocondensation
Schiff base
Mercapto acetic acid
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2019-03-01
3
2
251
260
10.22034/chemm.2018.149048.1089
77097
مقاله پژوهشی
Synthesis of 2-Amino-4H-chromene Derivatives under Solvent-Free Condition Using MOF-5
Zeinab Arzehgar
arzehgar@yahoo.com
1
Vahid Azizkhani
vahid.azizkhani1@gmail.com
2
Sami Sajjadifar
ss.sajjadifar@gmail.com
3
Mohammad Hossein Fekri
m.h.fekri@abru.ac.ir
4
Department of Chemistry, Payame Noor University, PO Box 19395‑4697, Tehran, Iran
Department of Chemistry, Payame Noor University, PO Box 19395‑4697, Tehran, Iran
Department of Chemistry, Payame Noor University, PO Box 19395‑4697, Tehran, Iran
Department of Chemistry, Ayatollah Alozma Borujerdi University, Borujerd, Iran
MOF-5 has been employed as a powerful catalyst for the preparation of 2-amino-4H-chromene. A wide variety of aromatic aldehydes was condensed with malononitrile and 2-naphthol under mild and solvent-free conditions in the presence of the trace amount of catalyst. A variety of 2-amino-4H-chromene can be obtained in good to excellent yield up to 95% in relatively short time reaction and easy workup.
https://www.chemmethod.com/article_77097_43874df1f6905c462ea45d049cf8cf07.pdf
MOF-5
Metal organic framwork
Solvent-free
2-Amino-4H-chromenes
eng
Sami Publishing Company
Chemical Methodologies
2645-7776
2588-4344
2019-03-01
3
2
261
275
10.22034/chemm.2018.155768.1109
79216
مقاله پژوهشی
Phthalimide Derivatives: New Promising Additives for Functional Electrolyte in Lithium-ion Batteries
Behrooz Mosallanejad
bmosallanejad@aut.ac.ir
1
Department of chemistry, Amirkabir University of Technology, Tehran, Iran
Vinylene carbonate (VC) is the most well-known additive for current lithium-ion batteries (LIBs). Low anodic stability or insufficient oxidation stability as a drawback of VC affected LIBs performance, especially in high voltage applications. As computational screening is faster and much less expensive than experimental trial and error testing, by using density functional theory (DFT) computations, phthalimide derivatives are screened as promising solid electrolyte interface (SEI) forming additives in LIBs. Our computational screening comprising frontier orbital energy, binding energy, and redox potentials shows that phthalimide derivatives are promising candidates as SEI-forming additives on graphite anode in ethylene carbonate (EC), and propylene carbonate (PC), based electrolytes. Additionally, four phthalimide derivatives including 3-nitrophthalimide, N-chlorophthalimide, 3,4,5,6-tetrachlorophthalimide, and phthalimide itself, due to their higher anodic stability and also reduction potential compared to VC, can be used as future alternatives of VC for LIBs.
https://www.chemmethod.com/article_79216_95a90bbfc4f8a1466c0ae87ab784b197.pdf
Electrolyte additive
DFT computation
Solid electrolyte interface
Lithium-ion battery
Phthalimide derivatives