%0 Journal Article %T Synthesis and Biological Activities of Some New Derivatives Based on 5-Styryl-2-amino-1,3,4-thiadiazole %J Chemical Methodologies %I Sami Publishing Company %Z 2645-7776 %A Narran, Shetha Fadhil %A Mohammed, Suad Salman %A Omer, Maab Khattab %A Hussein, Iftikhar Ahmed %A Jawad, Noor Mohammed %A Shweish, Batool Karim %D 2022 %\ 02/01/2022 %V 6 %N 2 %P 83-90 %! Synthesis and Biological Activities of Some New Derivatives Based on 5-Styryl-2-amino-1,3,4-thiadiazole %K 1,3,4-Thiadiazle %K Amic acid %K Imide %K anti-bacterial %K Anti-fungal %R 10.22034/chemm.2022.2.1 %X In this research, 5-Styryli-2-amino-1, 3, 4-thiadiazole [C1] was prepared from the reaction of acid 3-phenyl propenoic acid with thiosemicarbazide. Amic acids [C2-C5] were synthesized by reactive compound [C1] with different types of hydrides, then [C2, C4] were treated with AC2O in the presence of NaOAC as a catalyst giving Imide compounds [C6, C7]. The structure of the new derivatives was confirmed via FT-IR spectroscopy, some of which were confirmed via 1H-NMR spectroscopy. Three of these new derivatives were evaluated by their Esherichiacoli, Staphylococcus, and Rhizopus emporium. %U https://www.chemmethod.com/article_140134_0c6c5b6943001cfb0c119d33236de0ac.pdf