%0 Journal Article %T Synthesis, Biological Evaluations and Molecular Docking of Novel Pyrazolyl, Dihydro-1H-inden-1-one Derivatives %J Chemical Methodologies %I Sami Publishing Company %Z 2645-7776 %A Acharya, Ashok P. %A Gaikwad, Milind V. %A Dawane, Bhaskar S. %D 2022 %\ 04/01/2022 %V 6 %N 4 %P 339-346 %! Synthesis, Biological Evaluations and Molecular Docking of Novel Pyrazolyl, Dihydro-1H-inden-1-one Derivatives %K Molecular docking %K Antimicrobial %K Bleaching earth clay pH 12.5 %K PEG-400 α %K β -unsaturated ketones %R 10.22034/chemm.2022.329102.1441 %X A series of novel pyrazol-4-yl- dihydro-1H-inden-1-one derivatives were synthesized by using greener catalyst pH 12.5 (Bleaching earth clay BEC) as an efficient catalytic and PEG-400 as a green, recyclable solvent. All the synthesized compounds are characterized with 1HNMR, 13CNMR, IR and Mass Spectroscopy techniques. The synthesized molecules are subjected for the molecular docking study with 6KZV-A enzyme, the compounds IIb (E)-2-((1-(4-bromophenyl)-3-phenyl-1H-pyrazol-4-yl)methylene)-2,3-dihydro-1H-inden-1-one, IIc(E)-2-((3-phenyl-1-(p-tolyl)-1H-pyrazol-4-yl)methylene)-2,3-dihydro-1H-inden-1-one, IId (E)-2-((1-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-4-yl)methylene)-2,3-dihydro-1H-inden-1-one and IIe (E)-2-((1-(4- nitrophenyl)-3-phenyl-1H-pyrazol-4-yl)methylene)-2,3-dihydro-1H-inden-1-one shows the desired bonding interaction with 6KZV-A enzyme. The compounds further were evaluated for antimicrobial activities. Amongst these synthesized compounds, the mentioned compounds show good to moderate antimicrobial activities. %U https://www.chemmethod.com/article_146645_abc341593cb89523731b7676fef9ff96.pdf