%0 Journal Article %T Preparation and Identification of New 1,4-bis (5,3-substituted-2,3-dihydro-1H-pyrazole-1-yl) Buta-1,4-Dione Derivatives with Their Antibacterial Effect Evaluation %J Chemical Methodologies %I Sami Publishing Company %Z 2645-7776 %A Beebany, Shakhawan %A Jasim, Saad Salem %A M.Al-Tufah, Mohammad %A Arslan, Sevgi Samih Hidayet %D 2023 %\ 02/01/2023 %V 7 %N 2 %P 123-136 %! Preparation and Identification of New 1,4-bis (5,3-substituted-2,3-dihydro-1H-pyrazole-1-yl) Buta-1,4-Dione Derivatives with Their Antibacterial Effect Evaluation %K Pyrazole %K Cyclization %K Succinicdihydrazide %K Chalcones %K Butadione %K Antibacterial Effect %R 10.22034/chemm.2023.365060.1614 %X A new series of 5,3-substituted-2,3-dihydro-1H-pyrazole derivatives (P1-10) have been synthesized via a cyclization reaction of substituted chalcones with succinichydrazide. Structures of the prepared compounds were identified by FT-IR, and some of them were characterized by Nuclear Magnetic Resonance for proton 1H-NMR and Nuclear Magnetic Resonance for carbon 13C-NMR. The heat of formation (HF) and steric energy (SE) have been calculated using (MOPAC) and (MM2) methods, respectively, using (CS-Chemoffice-version 6.0) program. Additionally, the biological activity for final products has been evaluated against gram-positive (staphylococcus aureus and staphylococcus epidermidis) and negative bacteria (escherichia coli and pseudomonas aeruginosa).  %U https://www.chemmethod.com/article_160325_cd8b07fe6e4d099d913ae4c867f77eec.pdf