%0 Journal Article %T Synthesis, Characterization of Ethyl Dioxoisoindolinyl Cyclohexenone Carboxylate Derivatives from Some Chalcones and its Biological Activity Assessment %J Chemical Methodologies %I Sami Publishing Company %Z 2645-7776 %A M. Al-Tufah, Mohammad %A Beebaeny, Shakhawan %A Salem Jasim, Saad %A Lateef Mohammed, Bari %D 2023 %\ 05/01/2023 %V 7 %N 5 %P 408-418 %! Synthesis, Characterization of Ethyl Dioxoisoindolinyl Cyclohexenone Carboxylate Derivatives from Some Chalcones and its Biological Activity Assessment %K Dioxoisoindonyl %K Chalcones %K cyclohexenones %K Ethyl carboxylate %K Ethyl acetoacetate %K Cyclization %R 10.22034/chemm.2023.388126.1654 %X In this study, new ethyl dioxoisoindolinyl cyclohexenone carboxylate derivatives have been synthesized via addition and cyclocondensation reactions when ethylacetoacetate added to chalcone compounds in a strong alkaline media. Ethylacetoacetate was added to chalcone compounds (D1-D10) in ethanol as solvent to produce cyclohexenone compounds (D11-D20), using sodium hydroxide as catalyst. The prepared compounds structures have been identified using the infrared spectroscopy (FT-IR) and some of them by 1H-NMR and 13C-NMR spectroscopy. The chalcones were prepared from our earliest published work. These new cyclohexenones have been applied as antibacterial agent towards Staphylococcus aureus, Staphylococcus epidermidis (gram-positive bacteria), and Escherichia coli (gram-negative bacteria). The results exhibited good antibacterial activity of the synthesized compounds against Staphylococcus aureus and Staphylococcus epidermidis at high concentrations (0.01 and 0.001) mg/mL compared to low concentration (0.001 mg/mL) because of high concentration effect. %U https://www.chemmethod.com/article_168275_245a889b24f4b272257a591c6e31d286.pdf