TY - JOUR ID - 134965 TI - Sensitive Simultaneous Detection of Methyldopa and Hydrochlorothiazide on Ce3+-NiO Hexagonal Nanoparticles-Modified Electrode JO - Chemical Methodologies JA - CHEMM LA - en SN - 2645-7776 AU - Salaria, Sajedeh AU - Beitollahi, Hadi AD - Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran AD - Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran Y1 - 2021 PY - 2021 VL - 5 IS - 5 SP - 407 EP - 415 KW - glassy carbon electrode KW - Ce3+-NiO hexagonal nanoparticles KW - Methyldopa KW - Hydrochlorothiazide KW - Electrochemical sensor DO - 10.22034/chemm.2021.134965 N2 - We applied GCE modified with Ce3+-NiO hexagonal nanoparticles (Ce3+-NiO HNPs) for preparing methyldopa electrochemical sensor. Electrochemical study of the modified electrode showed that within the optimal conditions of phosphate buffer solution (PBS) at a pH of 7.0 in CV, oxidation potency of methyldopa decline to ~100 mV at the modified electrode in comparison with an unmodified GCE. The sensor exhibits a sensitive response to methyldopa in range between 0.1 and 80.0 μM with a limit of detection (LOD) equal to 0.03 μM. In addition, as sensing materials for simultaneously determine hydro-chlorothiazide and methyldopa, Ce3+-NiO HNPs/GCE, exhibited high sensitivity. The defined and separated oxidation peaks of a mixture of methyldopa and hydrochlorothiazide were obtained with significant peak potential differences of 390 V. The proposed electrochemical sensor was employed in analysis of both drugs in the real specimens.  UR - https://www.chemmethod.com/article_134965.html L1 - https://www.chemmethod.com/article_134965_bc483e4c0e0c56342adedd1591859603.pdf ER -