TY - JOUR ID - 168275 TI - Synthesis, Characterization of Ethyl Dioxoisoindolinyl Cyclohexenone Carboxylate Derivatives from Some Chalcones and its Biological Activity Assessment JO - Chemical Methodologies JA - CHEMM LA - en SN - 2645-7776 AU - M. Al-Tufah, Mohammad AU - Beebaeny, Shakhawan AU - Salem Jasim, Saad AU - Lateef Mohammed, Bari AD - Directorate of Education, Kirkuk, Ministry of Education, Iraq AD - Chemistry Department, College of Sciences, University of Kirkuk, Kirkuk, Iraq AD - Biology Department, College of Sciences, University of Kirkuk, Kirkuk, Iraq Y1 - 2023 PY - 2023 VL - 7 IS - 5 SP - 408 EP - 418 KW - Dioxoisoindonyl KW - Chalcones KW - cyclohexenones KW - Ethyl carboxylate KW - Ethyl acetoacetate KW - Cyclization DO - 10.22034/chemm.2023.388126.1654 N2 - In this study, new ethyl dioxoisoindolinyl cyclohexenone carboxylate derivatives have been synthesized via addition and cyclocondensation reactions when ethylacetoacetate added to chalcone compounds in a strong alkaline media. Ethylacetoacetate was added to chalcone compounds (D1-D10) in ethanol as solvent to produce cyclohexenone compounds (D11-D20), using sodium hydroxide as catalyst. The prepared compounds structures have been identified using the infrared spectroscopy (FT-IR) and some of them by 1H-NMR and 13C-NMR spectroscopy. The chalcones were prepared from our earliest published work. These new cyclohexenones have been applied as antibacterial agent towards Staphylococcus aureus, Staphylococcus epidermidis (gram-positive bacteria), and Escherichia coli (gram-negative bacteria). The results exhibited good antibacterial activity of the synthesized compounds against Staphylococcus aureus and Staphylococcus epidermidis at high concentrations (0.01 and 0.001) mg/mL compared to low concentration (0.001 mg/mL) because of high concentration effect. UR - https://www.chemmethod.com/article_168275.html L1 - https://www.chemmethod.com/article_168275_245a889b24f4b272257a591c6e31d286.pdf ER -