TY - JOUR ID - 50558 TI - Ultrasonic and Microwave Effects on the Benzamide/Sulfuryl Chloride Mediated Benzoylation of Benzene Derivatives under Vilsmeier-Haack Conditions JO - Chemical Methodologies JA - CHEMM LA - en SN - 2645-7776 AU - Venkateswarlu, Marri AU - Kumar, Mukka Satish AU - Kamatala, Chinna Rajanna AU - Venkanna, Purugula AU - Saiprakash, Pondichery Kuppuswamy AD - Department of Chemistry, Osmania University, Hyderabad-500 007, T.S., India Y1 - 2023 PY - 2023 VL - 7 IS - 9 SP - 650 EP - 658 KW - Ultrasonic and microwave irradiation KW - Benzamide/ SO2Cl2 KW - Rate accelerations DO - 10.48309/chemm.2023.50558 N2 - Benzamide/ Sulfuryl Chloride (SO2Cl2) reagent has been developed as a Vilsmeier- Haack(VH) reagent for benzoylation of aromatic compounds by using the conventional and ultrasonic sonication (US), and microwave (MW) conditions. Benzoylation is much more competent and faster than the analogous VH ((Benzamide/ POCl3) or (Benzamide/ SOCl2)) reagents and afforded benzoyl derivatives in good yields.  Reaction times are moderately less than those observed with [Benzamide/ POCl3] and (Benzamide/ SOCl2) reagents. Reaction times are far less in microwave assisted (MWAR) reactions than ultrasonically assisted (USAS) reactions , which in turn are less than the conventional method with a decreasing  trend: MWAR (seconds) << Sonication (minutes) << conventional (hrs). The highly remarkable rate accelerations in MW assisted reactions are attributed to the bulk activation of the molecules; while US assisted reactions could be accounted for cavitation effects.  UR - https://www.chemmethod.com/article_50558.html L1 - https://www.chemmethod.com/article_50558_63fe1022f839e2c28cbf3fe8541f3dbc.pdf ER -