Document Type: Original Article

Authors

Faculty of Sciences, Shahrekord University, Shahrekord, Iran

Abstract

Deep Eutectic Solvents (DES) with the properties of an ionic liquid can be formed between choline chloride and chloroacetic acid in a 1:1 molar ratio. In this paper, we discuss our success in synthesizing dihydropyrimidinones employing choline chloride: chloroacetic acid as catalyst. The advantage of using DES is in its ability to act as a solvent and catalyst simultaneously for the synthesis of dihydropyrimidinones via one-pot multi-component reaction of ethyl acetoacetate, aldehyde and urea. The results showed that choline chloride: chloroacetic acid based DES is the best catalyst and is successfully applicable to a wide range of aldehydes with high yields (70–95%) and short reaction times (5-75 min). The deep eutectic solvent can be easily recycled and reused.

Graphical Abstract

Highlights

Highlight

  • The Biginelli reaction catalyzed by choline chloride and chloroacetic acid as deep eutectic solvent.
  • The purification is easy and applicable for the large-scale synthesis.
  • The catalyst is recyclable.

Keywords

Main Subjects

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