Document Type: Short communication

Authors

1 Sreenidhi Institute of Science and Technology (Autonomous) Yamnampet, Ghatkesar, Hyderabad-501301, Telangana, India

2 Mahatma Gandhi University, Nalgonda, Telangana, India-508254

10.22034/chemm.2018.154218.1103

Abstract

A simple method was developed to synthesize N-(3-(4-Chlorophenoxy)benzyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine by coupling 3-(4-Chlorophenoxy)phenyl)methanamine and 4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine. The products have been obtained in good yields and were characterized by spectral analyses and finally, docking studies were carried out.

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Main Subjects

[1] Baraldi P.G., Tabrizi M.A., Gessi S., Borea P.A. Chem. Rev., 2008, 108:238

[2] Petricci E., Mugnaini C., Radi M., Togninelli A., Bernardini C., Manetti F., Parlato M.C., Renzulli M.L., Alongi M., Falciani C., Corelli F., Botta M. Arkivoc, 2006, 2006:452

[3] Manlove A., Groziak M.P. Prog. Heterocycl. Chem., 2009, 20:333

[4] Chamberlain S.D., Wilson J.W., Deanda F., Patnaik S., Redman A.M., Yang B., Shewchuk L., Sabbatini P., Leesnitzer M.A., Groy A., Atkins C., Gerding R., Hassell A.M., Lei H., Mook R.A., Moorthy J.G., Rowand J.L., Stevens K.L., Kumar R., Shotwell J.B. Bioorg. Med. Chem. Lett., 2009, 19:469

[5] Tangeda S.J., Garlapati A. Eur. J. Med. Chem., 2010, 45:1453

[6] Mohamed M.S., Kamel R., Fatahala S.S. Eur. J. Med. Chem., 2010, 45:2994

[7] Hilmy K.M.H, Khalifa M.M.A., Hawata M.A., Keshk R.M.A., El-Torgman A.A. Eur. J. Med. Chem., 2010, 45:5243

[8] Ghorab M.M., Ragab F.A., Heiba H.I., Youssef H.A., El-Gazzar M.G. Bioorg. Med. Chem. Lett., 2010, 20:6316

[9] McHardy T., Caldwell J.J., Cheung K.M., Hunter L.J., Taylor K., Rowlands M., Ruddle R., Henley A., deHaven Brandon A., Valenti M., Davies T.G., Fazal L., Seavers L., Raynaud F.I., Eccles S.A., Aherne G.W., Garrett M.D., Collins I. J. Med. Chem., 2010, 53:2239

[10] Gangjee A., Yang J., McGuire J.J., Kisliuk R.L. Bioorg. Med. Chem., 2006, 14:8590

[11] Janeba Z., Balzarini J., Andrei G., Snoeck R., De Clercq E., Robins M.J. J. Med. Chem., 2005, 48:4690

[12] Gangjee A., Kurup S., Ihnat M.A., Thorpe J.E., Shenoy S.S. Bioorg. Med. Chem., 2010, 18:3575

[13] Varaprasad C.V.N.S., Ramasamy S.K., Girardet J.L., Gunic E., Lai V., Zhong Z., An H., Hong Z. Bioorg. Chem., 2007, 35:25

[14] Koh Y.H., Shim J.H., Girardet J.L., Hong Z. Bioorg. Med. Chem. Lett., 2007, 17:5261  

[15] Moriarty K.J., Koblish H.K., Garrabrant T., Maisuria J., Khalil E., Ali F., Petrounia L.P., Crysler C.S., Maroney A.C., Johnson D.L., Galemmo R.A. Bioorg. Med. Chem. Lett., 2006, 16:5778

[16] Bikadi Z., Hazai E. J. Cheminform., 2009, 1:15