Chemical Methodologies

A Pioneered Homemade NAG-4SX3-3D Analyzer Coupled with Continuous Flow Injection Analysis New Approach for The On-Line Turbidimetric Measurements of Metronidazole in Pure and Pharmaceutical Formulations

Nagham Shakir Turkie; Sarah Faris Hameed

Volume 7, Issue 1 , January 2023, , Pages 53-66

https://doi.org/10.22034/chemm.2023.356013.1592

Abstract

The detection of metronidazole (MTZ) in pure and pharmaceutical formulations is now possible with a newly developed analytical technique based on turbidimetric measurement (from 0 to ... Read More

Determination of Fuconazole Using Flow Injection Analysis and Turbidity Measurement by a Homemade NAG-4SX3-3D Analyzer

Nagham Shakir Turkie; Sarah Faris Hameed

Volume 6, Issue 10 , October 2022, , Pages 731-749

https://doi.org/10.22034/chemm.2022.348264.1561

Abstract

The research work exemplifies a sensitive, rapid, and simple procedure for measuring fluconazole using turbidity-continuous flow injection analysis for the generation of white precipitate ... Read More The research work exemplifies a sensitive, rapid, and simple procedure for measuring fluconazole using turbidity-continuous flow injection analysis for the generation of white precipitate via the reaction of fluconazole with phosphotungestic acid, and detecting the attenuation of incident light caused by light colliding with the precipitate surface grain using the NAG-4SX3-3D analyzer to determine turbidity (0-180 ͦ). The linear range extended from 0.01-18 mmol.L-1 for fluconazole measurements were considerably lower than 0.5 RSD % for the repetition (n=6) for the concentration chosen (2, 13 mmol.L-1), with limit of detection=7.5342 ng/sample from the gradual dilution over the lowest concentration on the calibration graph , linear dynamic range (r = 0.9989), (correlation coefficient), percentage linearity (R2 percent = 99.79) traditional approaches (UV-spectrophotometric at λmax=260 nm with linear range (0.001-1) mmol.L-1, r=0.9987, R2=0.9973, R2%=99.73, and turbidimetric method with linear range (0.01-17) mmol.L-1 , r= 0.9869, R2=0.9740, R2%= 97.40 were compared with the suggested strategy. In comparison to the typical reference method's 10 mm irradiation, it was discovered, in addition to the technique's developed sensitivity and the use of minimal chemicals, that this approach is characterized by a dynamic system, which avoids precipitated particle setting during measurements. The results indicated that the developed method has a wide range of concentration with a high linearity and sensitivity. Furthermore, the continuous dilution in CFIA allows for the management of high or low concentrations, for a wider range of applications. The devised approach is believed to be the most acceptable for fluconazole molecule determination in pure and pharmaceutical formulations when compared with the reference methods. The method used in this research work is a pioneered developed approach and proved its success in determination of fluconazole in pure and pharmaceutical formulations.

A Novel Approach for Study of Surface Morphology & Roughness Analysis for Characterization of Precipitation Product at A Nanoscale Level via the Reaction of Fluconazole with Phosphomolybidic Acid

Sarah Faris Hameed; D. Nagham Shakir Turkie

Volume 6, Issue 5 , May 2022, , Pages 385-397

https://doi.org/10.22034/chemm.2022.332594.1450

Abstract

The purpose of this study is to combine FIA and AFM to explain surface morphology utilizing a newly developed instrument, the NAG-4SX3-3D analyzer. The study is dedicated on a new approach ... Read More

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Author = Nagham Shakir Turkie

A Pioneered Homemade NAG-4SX3-3D Analyzer Coupled with Continuous Flow Injection Analysis New Approach for The On-Line Turbidimetric Measurements of Metronidazole in Pure and Pharmaceutical Formulations

Abstract

Determination of Fuconazole Using Flow Injection Analysis and Turbidity Measurement by a Homemade NAG-4SX3-3D Analyzer

Abstract

A Novel Approach for Study of Surface Morphology & Roughness Analysis for Characterization of Precipitation Product at A Nanoscale Level via the Reaction of Fluconazole with Phosphomolybidic Acid

Abstract