Chemical Methodologies

Original Article

Synthesis, Identification, and Antibacterial Effect Assessment of Some New 1,4-Thiazepines, Derived from Substituted Diphenyl Acrylamides and Diphenyl Dienones

Saad Salem Jasim; Jawdat Hilmi Abdulwahid; Shakhawan Beebany; Bari Lateef Mohammed

Articles in Press, Accepted Manuscript, Available Online from 20 May 2023

https://doi.org/10.22034/chemm.2023.392659.1668

Abstract

Some new 1,4-thiazepine derivatives (J16-J30) have been successfully synthesized through the reaction between each of diphenyl acryl amides (J1-J10) and diphenyl dienones (J11-J15) ... Read More Some new 1,4-thiazepine derivatives (J16-J30) have been successfully synthesized through the reaction between each of diphenyl acryl amides (J1-J10) and diphenyl dienones (J11-J15) with ortho-mercapto aniline. The reaction was performed in an alkaline medium using ethanol as a solvent. The diphenyl acryl amides were prepared from the condensation reaction of para-substituted acetanilides with different para benzaldehydes, while para-substituted benzaldehydes were reacted with acetone to produce the diphenyl dienones. All the prepared compounds have been identified, using visible and ultraviolet radiation spectrum, and infrared spectrum. Some of the new synthesized compounds have been diagnosed and confirmed their structures by proton and carbon nuclear magnetic resonance spectrum (1H-NMR and 13C-NMR, respectively). The purity of prepared compounds was confirmed by relying on thin-layer chromatography (TLC) results. The biological effect of these derivatives was assessed against certain types of gram-positive bacteria (Streptococcus Pneumonia and Staphylococcus Aureus) and gram-negative bacteria (Escherichia Coli, Pseudomonas Aeruginosa, and Proteus Moralities). The results showed a high antibacterial effect towards both types of the used bacteria at high concentrations, while the prepared compounds behaved differently at low concentrations. The results indicated that most of new thiazepines revealed a high antibacterial effect towards both types of the tested bacteria at high concentrations (100 mg/mL), while behaved oppositely at low concentrations (10 and 50 mg/mL). This is related to high concentration effect resulting in an increase for inhibition zone diameter. The highest antibacterial effect was observed for compounds (J17, J19, J21, J24, J25, J26, J28, and J30) at 100 mg/mL. One of the reasons could be the presence of halogenes and nitro groups compared to the other compounds as a result of electron withdrawal groups role.

Original Article

Ultrasound-Assisted Preparation and Optimization of Natural Flavoring Nanoemulsion for Dairy Products Based on Pistacia Khinjuk in Lab Scale

Masoumeh Khanahmadi; Fatemeh Shahrezaei; Mahdieh Sharifi; Ghasem Rezanejade Bardajee

Articles in Press, Accepted Manuscript, Available Online from 23 May 2023

https://doi.org/10.22034/chemm.2023.382181.1649

Abstract

Encapsulation process is employed to preserve flavor from inadmissible interactions with food, minimizing flavor-flavor interactions, guarding in contradiction of light-induced reactions ... Read More

Original Article

Ag-SiO2 Nanoparticles: Benign, Expedient, and Facile Nano Catalyst in Synthesis of Decahydroacridines

Morteza Farajpour; Seyed Mohammad Vahdat; Seyed Meysam Baghbanian; Mehdi Hatami

Articles in Press, Accepted Manuscript, Available Online from 23 May 2023

https://doi.org/10.22034/chemm.2023.386678.1653

Abstract

A simple approach for component reaction between aldehydes, anilines or ammonium acetate, and dimedone in ethanol as a solvent is studied using Ag-SiO2 nanoparticles. This approach ... Read More

Original Article

Static and Dynamic Study of Novel 4-Formyl-N-Hexadecyl-N,N-Dimethylbenzenaminium Bromide Synthesized as a Corrosion Inhibitor Use in Petroleum Wells Acidizing Process

Zaidoun K. Kuraimid; Abd El-Aziz S. Fouda S. Fouda; Dawood S. Abid

Articles in Press, Accepted Manuscript, Available Online from 07 June 2023

https://doi.org/10.22034/chemm.2023.395919.1677

Abstract

This study showcases the innovative synthesis of 4-formyl-N-hexadecyl-N,N-dimethylbenzenaminium bromide (FHDB) using a reaction of 1-Bromohexadecane and 4-di methyl amino benzaldehyde. ... Read More

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Volume & Issue: Articles in Press

Synthesis, Identification, and Antibacterial Effect Assessment of Some New 1,4-Thiazepines, Derived from Substituted Diphenyl Acrylamides and Diphenyl Dienones

Abstract

Ultrasound-Assisted Preparation and Optimization of Natural Flavoring Nanoemulsion for Dairy Products Based on Pistacia Khinjuk in Lab Scale

Abstract

Ag-SiO2 Nanoparticles: Benign, Expedient, and Facile Nano Catalyst in Synthesis of Decahydroacridines

Abstract

Static and Dynamic Study of Novel 4-Formyl-N-Hexadecyl-N,N-Dimethylbenzenaminium Bromide Synthesized as a Corrosion Inhibitor Use in Petroleum Wells Acidizing Process

Abstract