Document Type : Original Article
Authors
1 Department of chemical engineering, Science and research branch, Islamic Azad University, Tehran, Iran
2 Department of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
3 Department of Pilot Nano biotechnology, Pasteur Institute of Iran, Tehran, Iran
Abstract
One of the most common causes of death in today's society is cancer. The treatments used in the treatment of cancers have their own side effects that have created many problems in the complete treatment of cancer. In classical and conventional drug delivery systems, the drug is distributed aimlessly and generally throughout the body, and the cells take part in the drug from the blood based on their position relative to the drug. As a result, a significant amount of the drug is wasted and eliminated without being used by the body. The most important disadvantages of the old methods of drug delivery are drug wastage, high cost of raw materials, the occurrence of side effects related to the dose, physical and chemical incompatibilities, as well as clinical drug interactions. Nano-liposomes are nanometer-scale liposomes that are one of the most useful drug delivery systems in the field of drug release and retention, which both provides a higher level than liposomes and increases solubility and access to bioavailability as well as improved drug release. Important reasons for the use of nano-liposomes in the pharmaceutical industry are their similarity to cell membranes and trapping of hydrophobic and hydrophilic substances, drug delivery to the target tissue, control of drug flow in the bloodstream and good biocompatibility. Another important feature of nano-liposomes is the coating of water-soluble drugs in the central aqueous portion and fat-soluble drugs within its bilayer membrane. Nano liposomes can be effective in reducing drug toxicity and increasing drug efficacy.
DOR: https://dorl.net/dor/20.1001.1.26457776.2021.5.2.6.2
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