Document Type: Original Article

Authors

Department of Chemistry, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru-560058, Karnataka, India

Abstract

A short and efficient protocol for the synthesis of novel α-aminophosphonate esters containing β-lactam moiety is described. Inexpensive and mild catalyst such as fumaric acid was used for the synthesis of α-aminophosphonate esters by reacting N-(4-methoxyphenyl)-2-(substituted) propiolactam-3-carbaldehyde with amine and triethylphosphite in acetonitrile at reflux. α-aminophosphonate esters containing β-lactam hybrids were obtained in good yield and purity.


A short and efficient protocol for the synthesis of novel α-aminophosphonate esters containing β-lactam moiety is described. Inexpensive and mild catalyst such as fumaric acid was used for the synthesis of α-aminophosphonate esters by reacting N-(4-methoxyphenyl)-2-(substituted) propiolactam-3-carbaldehyde with amine and triethylphosphite in acetonitrile at reflux. α-aminophosphonate esters containing β-lactam hybrids were obtained in good yield and purity.

Graphical Abstract

Highlights

  • A novel approach towards the synthesis of β-lactam-containing α-aminophosphonates
  • Mild reaction conditions
  • A mild catalyst Fumaric acid employed in the synthesis
  • A practical alternative for the synthesis of compounds containing acid and base sensitive functionalities

Keywords

Main Subjects

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