Chemical Methodologies
7.4 (Q1)
CiteScore2024
Q2
Web of Science

Synthesis of Hollow Fiber Membrane PES-Chitosan-Mg(OH)2 as a Candidate for Hemodialysis Membrane

Document Type : Original Article

Authors

Yosafat Bramantyasena Widyantaka
Sari Edi Cahyaningrum
Pirim Setiarso
Amaria Amaria

Department of Chemistry, Faculty Mathematics and Natural Science, Universitas Negeri Surabaya, Jalan Ketintang Surabaya 60231, East Java, Indonesia

https://doi.org/10.48309/chemm.2026.567420.2069
Abstract
Hemodialysis is a therapy for patients with chronic kidney failure using hollow fiber membranes. The use of hollow fiber membranes has encouraged the search for optimal, effective, and biologically safe formulations. This study aims to create, characterize, review the effectiveness and safety of PES-chitosan-Mg(OH)2 hollow fiber membranes as candidates for hemodialysis membranes. The combination of these three materials is expected to improve the effectiveness and safety of hemodialysis. This membrane was made using a phase inversion method with varying concentrations of chitosan-Mg(OH)2, then tested with FTIR, SEM, contact angle testing, flux, and BSA, urea, and creatinine rejection capabilities. FTIR results showed a shift in the –OH and –NH bands, indicating hydrogen interaction between PES and chitosan, as well as Mg²⁺ coordination with the chitosan amine group. Sample F3 with a 1% chitosan content showed the most optimal results with a porosity of 50.54%, a contact angle of 68.39°, a flux of 54.39 L/m²h, BSA rejection of 96.26%, and urea and creatinine rejection of 57.74% and 48.96%, respectively. APTT, PT, and hemolysis tests confirmed good biocompatibility (<2% hemolysis). Overall, the PES–chitosan–Mg(OH)₂ membrane shows potential as an alternative material for effective and biologically safe hemodialysis applications.

Graphical Abstract

Synthesis of Hollow Fiber Membrane PES-Chitosan-Mg(OH)2 as a Candidate for Hemodialysis Membrane

Keywords

Hemodialysis
Hollow Fiber
PES
Chitosan
Mg(OH)2

Subjects

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Chemical Methodologies
Volume 10, Issue 5
May 2026
Pages 556-565

  • Receive Date 20 December 2025
  • Revise Date 28 January 2026
  • Accept Date 05 February 2026

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