Chemical Methodologies
7.4 (Q1)
CiteScore2024
Q2
Web of Science

Insight into the Stability, Reactivity, Structural and Spectral Properties of the Anti, Syn-endo and Syn-exo Isomers of Bis(N-ethoxy-N-ethyl-dithiocarbamato)Nitrido Technetium-99m [99mTc-N(NOEt)2] Radiopharmaceutical

Document Type : Original Article

Author

Mehdi Nabati

Synthesis and Molecular Simulation Laboratory, Chemistry Department, Pars Isotope Company, P.O. Box: 1437663181, Tehran, Iran

https://doi.org/10.22034/chemm.2018.62758
Abstract
(Ethoxy(ethyl)amino)methanedithiol is used in nuclear medicines as a ligand for the preparation of diagnostic radiopharmaceuticals. Among the available radionuclide tracers, technetium-99m (99mTc) is a good choice for myocardial perfusion imaging. Among the various cardiac perfusion imaging agents, bis(N-ethoxy-N-ethyl-dithiocarbamato)nitride technetium-99m radiopharmaceutical has a very high uptake. During the present study, the reactivity, stability, structural and spectral properties of anti, syn-endo and syn-exo isomers of bis(N-ethoxy-N-ethyl-dithiocarbamato)nitride technetium-99m radiopharmaceutical were discussed by density functional theory (DFT) computational method. It can be deduced from the theoretically applied computations that the anti- molecular structure is generally more stable than the syn-endo- and syn-exo- ones.

Graphical Abstract

Insight into the Stability, Reactivity, Structural and Spectral Properties of the Anti, Syn-endo and Syn-exo Isomers of Bis(N-ethoxy-N-ethyl-dithiocarbamato)Nitrido Technetium-99m [99mTc-N(NOEt)2] Radiopharmaceutical

Keywords

Coronary Artery Disease
Density functional theory
Nuclear medicine
Radiopharmaceutical
99mTc-N(NOEt)2

Subjects

[1]. Nabati M., Mahkam M. Iran Chem. Commun., 2014, 2:129
[2]. Fagret D., Ghezzi C., Vanzetto G. J. Nucl. Med., 2001, 42:1395
[3]. Hatada K., Riou L.M., Ruiz M., Yamamichi Y., Duatti A., Lima R.L., Goode A.R., Watson D.D., Beller G.A., Glover D.K. J. Nucl. Med., 2004, 45:2095
[4]. Nabati M. Iran. J. Org. Chem., 2017, 9:2045
[5]. Takahana K., Beller G.A., Ruiz M., Petruzella F.D., Watson D.D., Glover D.K. J. Nucl. Med., 2001, 42:1388
[6]. Nabati M., Salehi H. Iran. J. Org. Chem., 2017, 9:2013
[7]. Nabati M., Mofrad M.H., Kermanian M., Sarshar S. Iran. J. Org. Chem., 2017, 9:1981
[8]. Nabati M., Kermanian M., Maghsoudloo-Mahalli A., Sarshar S. Iran. J. Org. Chem., 2017, 9:2067
[9]. Hernandez-Valdes D., Blanco-Gonzalez A., Garcia-Fleitas A., Rodriguez-Riera Z., Meola G., Alberto R., Jauregui-Haza U. J. Mol. Graph. Model., 2017, 71:167
[10]. Lamb J., Holland J.P. J. Nucl. Med., 2018, 59:382
[11]. Dijk J.D.V., Jager P.L., Osch J.A.C.V., Dalen J.A.V. J. Nucl. Med., 2017, 58:518
[12]. Nabati M., Kermanian M., Mohammadnejad-Mehrabani H., Kafshboran H.R., Mehmannavaz M., Sarshar S. Chem. Method., 2018, 3:132
[13]. Nabati M. Chem. Method., 2017, 2:128
[14]. Hernandez-Valdes D., Alberto R., Jauregui-Haza U. RSC Adv., 2016, 6:107127
[15]. Nabati M. Iran. J. Org. Chem., 2018, 10:2291
[16]. Renaud J.M., Yip K., Guimond J., Trottier M., Pibarot P., Turcotte E., Maguire C., Lalonde L., Gulenchyn K., Farncombe T., Wisenberg G., Moody J., Lee B., Port S.C., Turkington T.G., Beanlands R.S., DeKemp R.A. J. Nucl. Med., 2017, 58:103
[17]. Nabati M., Maghsoudloo-Mahalli A., Mohammadnejad-Mehrabani H., Movahed-Tazehkand H. Iran. J. Org. Chem., 2018, 10:2281
[18]. Cittanti C., Uccelli L., Pasquali M., Boschi A., Flammia C., Bagatin E., Casali M., Stabin M.G., Feggi L., Giganti M., Duatti A. J. Nucl. Med., 2008, 49:1299
[19]. Nabati M., Maghsoudloo-Mahalli A. Iran. J. Org. Chem., 2017, 9:2239
[20]. Bolzati C., Cavazza-Ceccato M., Agostini S., Refosco F., Yamamichi Y., Tokunaga S., Carta D., Salvarese N., Bernardini D., Bandoli G. Bioconjugate Chem., 2010, 21:928
[21]. Nabati M., Mohammadnejad-Mehrabani H. Iran. J. Org. Chem., 2017, 9:2117
[22]. Maria L., Soares M., Santos I.C., Sousa V.R., Mora E., Marcalo J., Luzyanin K.V. Dalton Trans., 2016, 45:3778
[23]. Nabati M., Mahkam M. Org. Chem. Res., 2016, 2:70
[24]. Nabati M. Iran. J.Org. Chem., 2016, 8:1935
[25]. Nabati M., Mahkam M. J. Phys. Theor. Chem., 2015, 12:121
[26]. Nabati M. J. Phys. Theor. Chem., 2015, 12:325
[27]. Nabati M. J. Phys. Theor. Chem., 2017, 14:49
[28]. Nabati M., Mahkam M. J. Phys. Theor. Chem., 2015, 12:33
[29]. Nabati M., Mahkam M., Atani Y.G. J. Phys. Theor. Chem., 2016, 13:35
[30]. Nabati M. J. Phys. Theor. Chem., 2016, 13:133
[31]. Moura C., Gano L., Mendes F., Raposinho P.D., Abrantes A.M., Botelho M.F., Santos I., Paulo A. Eur. J. Med. Chem., 2012, 50:350
[32]. Nabati M., Mahkam M. Inorg. Chem. Res., 2016, 1:131
[33]. Nabati M., Mahkam M. Silicon, 2016, 8:461
[34]. Nabati M. Iran. J. Org. Chem., 2015, 7:1631
[35]. Qian W., Zhang W., Zong H., Gao G., Zhou Y., Zhang C. J. Mol. Model., 2016, 22:9
[36]. Nabati M. Iran. J. Org. Chem., 2015, 7:1669
[37]. Nabati M. Iran. J. Org. Chem., 2016, 8:1703
[38]. Nabati M., Hojjati M. Iran. J. Org. Chem., 2016, 8:1777
[39]. Nabati M. Iran. J. Org. Chem., 2016, 8:1803
[40]. Nabati M. Iran. J. Org. Chem., 2016, 8:1817
[41]. Maurer R.I., Blower P.J., Dilworth J.R., Reynolds C.A., Zheng Y., Mullen G.E.D. J. Med. Chem., 2002, 45:1420
[42]. Gancheff J., Kremer C., Kremer E., Ventura O.N. J. Mol. Struct: THEOCHEM, 2002, 580:107
[43]. Okoye C.M.I. J. Phys: Condens. Matter., 2003, 15:5945
[44]. Zhang Y., Sun Y., Xu X., Zhang X., Zhu H., Huang L., Qi Y., Shen Y. J. Med. Chem., 2010, 53:3262
[45]. Banerjee P., Sproules S., Weyhermuller T., George S.D., Wieghardt K. Inorg. Chem., 2009, 48:5829
[46]. Gong Y., Zhou M., Andrews L. Chem. Rev., 2009, 109:6765
[47]. Sproules S., Benedito F.L., Bill E., Weyhermuller T., George S.D., Wieghardt K. Inorg. Chem., 2009, 48:10926
Chemical Methodologies
Volume 2, Issue 3 - Serial Number 1
Summer 2018
Pages 223-238

  • Receive Date 17 March 2018
  • Revise Date 27 April 2018
  • Accept Date 21 May 2018

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